Signal-amplified Colorimetric Biosensors Using Gold Nanoparticles

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  • MUTO Yu
    Department of Chemistry and Biology, Graduate School of Science and Engineering, Ehime University Tokyo Research Center, TOSOH Corporation
  • ZAKO Tamotsu
    Department of Chemistry and Biology, Graduate School of Science and Engineering, Ehime University

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Other Title
  • 金ナノ粒子を用いるカロリメトリックバイオセンサー
  • キン ナノ リュウシ オ モチイル カロリメトリックバイオセンサー

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Description

<p>Gold nanoparticles with diameters of several to several tens of nanometers dispersed in a solution exhibit a brilliant red color, but when they aggregate due to external factors, their absorption wavelength redshifts, which causes them to change to purple or blue color. Utilizing this large color change associated with the dispersion and aggregation of gold nanoparticles, sensors that can detect various molecules, such as biomolecules (DNA, proteins, etc.), metal ions, and organic molecules, have been constructed. However, the color change of gold nanoparticles cannot be observed without a large change in the dispersion/aggregation state, which makes it difficult to construct a highly sensitive measurement system. Therefore, in recent years, various sensors using signal amplification mechanisms have been proposed to detect targets with low concentrations. In this review, we outline the optical properties of gold nanoparticles related to light absorption and the dispersion stability of gold nanoparticles. We also introduce a sensor using the color change of gold nanoparticles and a signal amplification mechanism to increase the sensitivity of the sensor.</p>

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 70 (12), 661-670, 2021-12-05

    The Japan Society for Analytical Chemistry

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