Prevalence of the Use of Oral Contraceptives and Hormone Replacement Therapy in Japan: The Japan Nurses’ Health Study

DOI IR Web Site PubMed Research Data 8 Citations 27 References Open Access
  • Yasui Toshiyuki
    Department of Reproductive and Menopausal Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Ideno Yuki
    Center for Mathematics and Data Science, Gunma University
  • Shinozaki Hiromitsu
    Graduate School of Health Sciences, Gunma University
  • Kitahara Yoshikazu
    Department of Obstetrics and Gynecology, Gunma University Graduate School of Medicine
  • Nagai Kazue
    Graduate School of Health Sciences, Gunma University
  • Hayashi Kunihiko
    Graduate School of Health Sciences, Gunma University

Bibliographic Information

Published
2022-03-05
Resource Type
journal article
DOI
  • 10.2188/jea.je20200207
Publisher
Japan Epidemiological Association

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<p>Background: There have been few community-based epidemiological studies in which the prevalence of exogenous hormone use, including the use of oral contraceptives (OCs) and hormone replacement therapy (HRT), has been accurately assessed in Japan.</p><p>Methods: We have been conducting repeated surveys of participants in the Japan Nurses’ Health Study (JNHS), as a nationwide prospective cohort study, since 2001. We determined the prevalence of exogenous hormone use at baseline and during a 10-year follow-up period. A total of 15,019 female nurses participated in the JNHS follow-up cohort. We determined the prevalence of OC use in 14,839 women <60 years of age at baseline and the prevalence of HRT use in 7,915 women, excluding premenopausal women, at the last time they answered a questionnaire. The duration of HRT use was estimated using the Kaplan-Meier method.</p><p>Results: Six percent of the participants used OCs. The proportion of HRT users who stopped HRT before the baseline survey, the proportion of women using HRT during the follow-up period, and the proportion of all of the participants who had used HRT were 3.2%, 10.6%, and 13.8%, respectively. The median duration of HRT use was 2 years.</p><p>Conclusions: The lifetime prevalences of exogenous hormone use during this prospective study conducted in Japanese nurses were 6.0% for OCs and 13.8% for HRT. The information obtained in this study will be useful for clarification of the association between exogenous estrogen exposure and estrogen-related diseases as future research.</p>

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