A Case of Endocrine Cell Carcinoma of the Ascending Colon Successfully Treated with mFOLFOX6 Plus Bevacizumab.

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  • KUGIMIYA Naruji
    Department of Surgery, Yamaguchi Saiseikai Shimonoseki General Hospital Department of Surgery And Clinical Science(SurgeryⅠ),Yamaguchi University Graduate School of Medicine
  • KOBAYASHI Seiki
    Department of Surgery, Yamaguchi Saiseikai Shimonoseki General Hospital
  • SHIGETA Masatoshi
    Department of Surgery, Yamaguchi Saiseikai Shimonoseki General Hospital
  • UEKI Kouichi
    Department of Surgery, Yamaguchi Saiseikai Shimonoseki General Hospital
  • ENOKI Tadahiko
    Department of Surgery And Clinical Science(SurgeryⅠ),Yamaguchi University Graduate School of Medicine
  • HAMANO Kimikazu
    Department of Surgery And Clinical Science(SurgeryⅠ),Yamaguchi University Graduate School of Medicine

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Other Title
  • Bevacizumab併用mFOLFOX6療法が奏効した上行結腸内分泌細胞癌の１例
  • Bevacizumab ヘイヨウ mFOLFOX6 リョウホウ ガ ソウコウ シタ ジョウコウ ケッチョウ ナイブンピツ サイボウ ガン ノ 1レイ
  • 症例報告 Bevacizumab併用mFOLFOX6療法が奏効した上行結腸内分泌細胞癌の1例
  • ショウレイ ホウコク Bevacizumab ヘイヨウ mFOLFOX6 リョウホウ ガ ソウコウ シタ ジョウギョウ ケッチョウ ナイブンピ サイボウガン ノ 1レイ

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We report a case of effective treatment of mFOLFOX6 plus bevacizumab for endocrine cell carcinoma of ascending colon. A 79-year-old man was admitted for abdominal pain and fullness. Colonoscopy showed a tumor with ulceration in the ascending colon and the tumor was diagnosed by the biopsy as carcinoma combined with small cell carcinoma. Right hemicolectomy was done(stageⅣ,SiN3M1)and endocrine cell carcinoma was diagnosed finally by histological examination because of positive immunohistochemical staining with chromograninA and synaptophysin. One month after the surgery, multiple lymph nodes, liver and lumbar spine metastasis were found in CT. mFOLOFOX6 plus bevacizumab chemotherapy was started. After 4 cycles of the therapy, the tumor diminished and the patient has remained progression free. Endocrine cell carcinoma of the colon is rare and an effective chemotherapy has not been established. We report this case with a review of the literature.

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