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- 國木 悠理香
- 徳島大・院医歯薬・臨床薬理学
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- 八木 健太
- 徳島大学病院・総合臨床研究セ
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- 吉田 莉奈
- 徳島大・医・臨床薬理学
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- 岡本 尚大
- 徳島大・院医歯薬・臨床薬理学 徳島大学病院・薬剤部
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- 安藤 里英
- 徳島大・院医歯薬・臨床薬理学 徳島大学病院・薬剤部
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- 山川 裕介
- 徳島大学病院・薬剤部
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- 濱野 裕章
- 徳島大学病院・総合臨床研究セ
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- 新村 貴博
- 徳島大学病院・薬剤部
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- 相澤 風花
- 徳島大学病院・薬剤部
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- 石澤 有紀
- 徳島大・院医歯薬・薬理学
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- 合田 光寛
- 徳島大・院医歯薬・臨床薬理学 徳島大学病院・薬剤部
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- 座間味 義人
- 徳島大・院医歯薬・臨床薬理学 岡山大学病院・薬剤部
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- 石澤 啓介
- 徳島大・院医歯薬・臨床薬理学 徳島大学病院・薬剤部
書誌事項
- タイトル別名
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- The Effect of Combined Bcr-Abl Inhibitor and ALDH Inhibitor on Chronic Myelogenous Leukemia
抄録
<p>【Introduction】Chronic myelogenous leukemia (CML) has become a disease with five-year-survival rate of more than 90% according to appearance of Bcr-Abl inhibitor. Stopping treatment with Bcr-Abl inhibitors leads to relapse in many patients. This is due to the fact that Bcr-Abl inhibitors are not effective against cancer stem cells, and suggests that a different drug is necessary to eradicate cancer stem cells. ALDH is overexpressed in cancer stem cells and promotes their survival. We have shown in past studies that Bcr-Abl inhibitors do not inhibit ALDH expression. In this study, we examine the effect of ALDH inhibitors on CML.</p><p>【Methods】We examined the effects of an ALDH inhibitor using K562 cells, which are CML cell line. We verified the effect of an ALDH inhibitor against CML using a WST-8 assay. We then measured ALDH protein expression using flow cytometry.</p><p>【Results】ALDH inhibitors reduced cell survival in a concentration-dependent manner, and when combined with a Bcr-Abl inhibitor, cell viability was synergistically decreased. ALDH protein expression was decreased in cells treated with ALDH inhibitor alone or Bcr-Abl inhibitor alone according to flow cytometry. In cells treated with ALDH inhibitor and Bcr-Abl inhibitor, ALDH protein expression was more strongly repressed.</p><p>【Conclusion】The results of this study suggest that ALDH inhibitor use might be effective in CML treatment.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 95 (0), 1-SS-66-, 2022
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390573242652851072
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可