ニコチン離脱時の嫌悪行動における腹側分界条床核内ノルアドレナリン神経情報伝達の役割

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  • Role of noradrenergic transmission within the ventral bed nucleus of the stria terminalis in nicotine withdrawal-induced aversive behavior

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<p>Cessation of smoking leads to nicotine withdrawal symptoms such as anxiety, depression, and dysphoria, which could lead to smoking relapse. Therefore, it is necessary to clarify the neural mechanisms of nicotine withdrawal-induced negative emotions. We have previously reported that noradrenergic transmission in the ventral bed nucleus of the stria terminalis (vBNST) plays a crucial role in pain-induced aversion. To investigate the role of intra-vBNST noradrenergic transmission in nicotine withdrawal-induced aversion, a conditioned place aversion (CPA) test and in vivo microdialysis were conducted. Male Sprague-Dawley rats were used. Each animal was subcutaneously implanted with a nicotine- or saline-filled osmotic pump on day 1. Nicotine was continuously administered at 4.8 mg/kg/day. Nicotine withdrawal was precipitated by administration of mecamylamine (3.0 mg/kg) on day 15. Noradrenaline release in the vBNST was increased after mecamylamine administration in the nicotine group, but not in the saline group. Nicotine withdrawal induced aversive behavior, which was attenuated by intra-vBNST injection of timolol, a β-adrenoceptor antagonist. These results suggest that enhanced noradrenergic transmission in the vBNST during nicotine withdrawal plays an important role in nicotine withdrawal-induced aversive behavior.</p>

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