Gut microbiota in children with lower urethral disorders and functional constipation

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  • Ishikawa Takuya
    Department of Pediatrics, Showa University Fujigaoka Hospital
  • Ikeda Hirokazu
    Department of Pediatrics, Showa University Fujigaoka Hospital
  • Fuyama Masaki
    Department of Pediatrics, Showa University Fujigaoka Hospital
  • Ogawa Rei
    Department of Pediatrics, Showa University Fujigaoka Hospital
  • Fujimoto Yoko
    Department of Pediatrics, Showa University Fujigaoka Hospital

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  • 機能性便秘症を伴う下部尿路障害を有する小児における腸内細菌叢の検討

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Abstract

Many bacteria inhabit the human intestine and form the gut microbiota. Recently, the relationship between changes in the gut microbiota and various diseases has been reported. This study aimed to investigate the distribution of gut microbiota in children with lower urethral disorders and functional constipation. We sampled intestinal bacteria in 10 children with lower urethral disorders and functional constipation （8 boys, 2 girls; average age, 8.1 years） and 10 healthy children （10 boys; average age, 7.1 years）. We cultured these intestinal bacterial samples and identified four bacteria. Our results revealed that, Clostridium and Lactobacillus were significantly increased in children with lower urinary urethral disorders and functional constipation （p＜0.05）. No significant differences were found in other bacterial species and total bacterial count. Changes in the gut microbiota may affect urination and defecation. Probiotics may improve underlying disease and lower urinary tract abnormalities.

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