書誌事項
- タイトル別名
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- ホスホリパーゼ オ モチイタ キノウセイ カゴウブツ ノ リン シシツ ユウドウカホウ ニ カンスル ケンキュウ
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type:Article
Here I describe about the phosphatidylation of functional compounds using phospholipases which is covered with my doctoral thesis. Physiologically active compound such as conjugated fatty acid, terpenes and phenolic compounds sometime exert their activity not fully because of their poor solubility in a certain environment. On the other hand, phospholipids have characteristic amphiphilic property and biocompatibility. In this study, several physiologically active compounds were phosphatidylated using phospholipases such as phospholipase A2 and phospholipase D. The enzymatic reaction was modified and optimized for the yield. In addition, the phosphatidylated compounds were tested for their physiological activity in vitro. Conjugated linoleic acids which have anti-obesity effects were phosphatidylated mediated by phospholipase A2. In this reaction, it is fund that water mimics such as formamide was key factor for the synthetic reaction. Several terpenes and phenolic compounds which have anti-cancer effects or anti-oxidative effects were phosphatidylated mediated by phospholipase D. Some phosphatidylated compounds were exerted higher anti-cancer effects compare to parent compounds.
identifier:http://repository.seikei.ac.jp/dspace/handle/10928/147
収録刊行物
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- 成蹊大学理工学研究報告 = The journal of the Faculty of Science and Technology, Seikei University
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成蹊大学理工学研究報告 = The journal of the Faculty of Science and Technology, Seikei University 48 (2), 59-62, 2011-12-01
成蹊大学理工学部
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詳細情報 詳細情報について
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- CRID
- 1390573242703259648
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- NII論文ID
- 40019173356
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- NII書誌ID
- AA1203510X
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- ISSN
- 18802265
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- NDL書誌ID
- 023459029
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- IRDB
- NDL
- CiNii Articles