Antibacterial activity of Psidium guajava leaf and bark against multidrug-resistant Vibrio cholerae: implication for cholera control

DOI Web Site Web Site

書誌事項

タイトル別名
  • Antibacterial Activity of <i>Psidium guajava</i> Leaf and Bark against Multidrug-Resistant <i>Vibrio cholerae</i>: Implication for Cholera Control

この論文をさがす

抄録

<p>In clinical cholera, a 3-day course of antibiotic complements extensive rehydration therapy by reducing stool volume, shortening the illness, and averting death. However, antibiotic therapy, which has lifesaving implications for cholera, is often hindered due to multidrug resistance in Vibrio cholerae, the cause of cholera. Crude aqueous mixture and water soluble methanol extract from leaf and bark of Psidium guajava, a tropical fruit guava of the family Myrtaceae, showed strong antibacterial activity against multidrug-resistant V. cholerae O1. The in vitro minimum inhibitory concentration of the crude aqueous mixture and water soluble methanol extract, which was bactericidal against 107 CFU/mL of V. cholerae was determined to be 1,250 μg/mL and 850 μg/mL, respectively. The antibacterial activity of P. guajava was stable at 100ºC for 15–20 min, suggesting nonprotein nature of the active component. The growth of V. cholerae in rice oral rehydration saline (ORS) was completely inhibited when 10 mg/mL (wt/vol) of crude aqueous mixture was premixed with the ORS in a ratio of 1:7 (vol. extract/vol. ORS). P. guajava, which is widely distributed in Bangladesh, thus offers great potential for use in indigenous, herbal medicine for controlling epidemics of cholera.</p>

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ