Fatal necrotizing pneumonia caused by Panton-Valentine leukocidin-producing hospital-acquired Staphylococcus aureus: a case report

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  • Al-Talib Hassanain
    Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Malaysia
  • Hasan Habsah
    Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Malaysia
  • Yean Chan Yean
    Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Malaysia
  • Al-Ashwal Sami M.
    Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Malaysia
  • Ravichandran Manickam
    Faculty of Applied Sciences, Asian Institute of Medicine, Science and Technology University, Malaysia

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  • Fatal Necrotizing Pneumonia Caused by Panton-Valentine Leukocidin-Producing Hospital-Acquired <i>Staphylococcus aureus</i>: a Case Report

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<p>Panton-Valentine leukocidin (PVL) is a cytotoxin which causes leukocyte destruction and tissue necrosis. Although it is produced by fewer than 5% of Staphylococcus aureus strains, PVL-producing S. aureus is emerging as a serious problem worldwide. There has been a marked increase in the incidence of necrotizing lung infections with a very high mortality associated with these strains. This report describes a fatal case of hospital-acquired necrotizing pneumonia caused by PVL-positive methicillin-susceptible S. aureus in a patient with a brain tumor.<tt> </tt></p>

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