Transplantation of skin grafts and organs infected with Toxoplasma gondii as a source of toxoplasmosis in immunocompromised mice

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  • Belal Usama Salah
    Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Japan Department of Parasitology, Faculty of Medicine, Minia University, Egypt
  • Norose Kazumi
    Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Japan
  • Mohamed Rabie Mohamed
    Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Japan Department of Parasitology, Faculty of Medicine, Minia University, Egypt
  • Naoi Koji
    Medical Corporation Koseikai of Chiba, Japan
  • Yano Akihiko
    Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Japan

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  • Transplantation of Skin Grafts and Organs Infected with <i>Toxoplasma gondii</i> as a Source of Toxoplasmosis in Immunocompromised Mice

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<p>The possibility of Toxoplasma gondii infection resulting from transplantation of a skin graft and various organs has been investigated. The parasite was detected in very low numbers in all organs examined in wild-type (WT) BALB/c (B/c) mice that received skin grafts from infected interferon gamma knockout (GKO) B/c mice both with and without sulfamethoxazole treatment; all recipient mice survived. In contrast, transplantation of skin grafts from untreated infected WT B/c mice to naïve GKO B/c mice led to the death of all recipients within 20 days post-transplantation; T. gondii was found to be disseminated in all organs examined. Similar results were obtained after transplantation of skin from untreated and treated GKO B/c mice to naïve GKO B/c mice, whereas the recipient GKO B/c mice died within 10 days after intraperitoneal transplantation of lung, heart, brain or small intestine from infected untreated GKO B/c mice. These results indicate that skin grafts as well as various organs infected with T. gondii can be sources of infection in immunocompromised hosts. Toxoplasmosis should therefore be taken into consideration during organ transplantation to immunocompromised hosts.<tt> </tt></p>

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