The Adverse Events of Influenza A (H1N1) Vaccination and Its Risk Factors in Healthcare Personnel in 18 Military Healthcare Units in Korea

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  • Hwang Se-Min
    Department of Preventive Medicine, Armed Forces Medical Command, Korea
  • Choe Kang-Won
    Department of Internal Medicine, Armed Forces Capital Hospital, Korea
  • Cho Sang-Heon
    Department of Internal Medicine, Seoul National University College of Medicine, Korea Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Korea
  • Yoon Seok-Jun
    Department of Preventive Medicine, Health Policy and Hospital Management Graduate School of Public Health, Korea University, Korea
  • Park Dong-Ean
    Department of Preventive Medicine, Armed Forces Medical Command, Korea
  • Kang Jum-Sook
    Department of Preventive Medicine, Armed Forces Medical Command, Korea
  • Kim Min-Jeong
    Korea University School of Public Health, Korea
  • Chun Byung-Chul
    Department of Preventive Medicine, Korea University College of Medicine, Korea Department of Epidemiology Public Health Informatics, Korea University School of Public Health, Korea
  • Lee Sang-Min
    Department of Internal Medicine, Armed Forces Capital Hospital, Korea

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<p>In this study, we characterized adverse events related to influenza A (H1N1) vaccination and studied the factors that influence the occurrence of these events. A total of 4,302 personnel in 18 military healthcare units in Korea received 0.5 ml of inactivated H1N1 vaccine. The study questionnaires were answered by 3,939 (91.6%) personnel, at both 2 weeks and 4 weeks after vaccination. Among these subjects, 3,531 (82.1%) who responded to all questions in the questionnaire were studied. After immunization, military doctors were ordered to report the occurrence of any adverse event related to the vaccine for 2 months. According to the responses of the subjects, the most prevalent events were fatigue (11.3%), pain at the injection site (8.38%), and myalgia (6.97%). Female gender, being in the age range of 20–49 years, obesity, regular alcohol consumption, and comorbidity, but not smoking status or pregnancy, were related to a high incidence of local or systemic adverse events after H1N1 vaccination. A total of 14 cases of adverse events were reported by the military doctors. In most reported cases, the subjects had fever in addition to the primary adverse event, and one patient was diagnosed with pneumonia. In conclusion, the overall burden of adverse events related to influenza A (H1N1) vaccination was not inconsequential, but most symptoms were mild. Female gender, middle-age range of 20-49 years, obesity, regular alcohol consumption, and comorbidity were risk factors for the occurrence of adverse events after H1N1 vaccination.<tt> </tt></p>

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