Gene expression analysis of host innate immune responses in the central nervous system following lethal CVS‐11 infection in mice

DOI Web Site Web Site 被引用文献3件
  • Sugiura Naoko
    Department of Veterinary Science, National Institute of Infectious Diseases, Japan United Graduate School of Veterinary Science, Gifu University, Japan
  • Uda Akihiko
    Department of Veterinary Science, National Institute of Infectious Diseases, Japan
  • Inoue Satoshi
    Department of Veterinary Science, National Institute of Infectious Diseases, Japan United Graduate School of Veterinary Science, Gifu University, Japan
  • Kojima Daisuke
    Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, Japan
  • Hamamoto Noriko
    Department of Veterinary Science, National Institute of Infectious Diseases, Japan United Graduate School of Veterinary Science, Gifu University, Japan
  • Kaku Yoshihiro
    Department of Veterinary Science, National Institute of Infectious Diseases, Japan
  • Okutani Akiko
    Department of Veterinary Science, National Institute of Infectious Diseases, Japan
  • Noguchi Akira
    Department of Veterinary Science, National Institute of Infectious Diseases, Japan
  • Park Chun-Ho
    Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, Japan
  • Yamada Akio
    Department of Veterinary Science, National Institute of Infectious Diseases, Japan United Graduate School of Veterinary Science, Gifu University, Japan

書誌事項

タイトル別名
  • Gene Expression Analysis of Host Innate Immune Responses in the Central Nervous System following Lethal CVS-11 Infection in Mice

この論文をさがす

抄録

<p>The central nervous system (CNS) tissue of mice infected with the CVS-11 strain of rabies virus (RABV) was subjected to gene expression analysis using microarray and canonical pathway analyses. Genes associated with innate immunity as well as inflammatory responses were significantly up-regulated, corroborating with the previous findings obtained using attenuated viruses that did not induce a fatal outcome in infected mice. Histopathological examination showed that neurons in the cerebellum had undergone apoptosis. Although the extent of Fas ligand up-regulation was not so prominent, perforin and granzyme genes were highly expressed in the CNS of mice infected with CVS-11. The presence of perforin and granzymes both in the Purkinje cells and CD3 T lymphocytes strongly suggested that apoptosis of the former cells was induced by the latter cells.<tt> </tt></p>

収録刊行物

被引用文献 (3)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ