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- SAWAYAMA Yasushi
- Department of Hematology, Nagasaki University Hospital
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- KATO Takeharu
- Department of Hematology, Nagasaki University Hospital
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- WATANABE Haruka
- Department of Hematology, Nagasaki University Hospital
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- YAMADA Yuichi
- Department of Hematology, Nagasaki University Hospital
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- FUJIOKA Machiko
- Department of Hematology, Nagasaki University Hospital
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- SATO Shinya
- Department of Hematology, Nagasaki University Hospital
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- BABA Maki
- Department of Hematology, Nagasaki University Hospital
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- ANDO Koji
- Department of Hematology, Nagasaki University Hospital
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- MIYAZAKI Teiichiro
- Department of Neurology and Strokology, Nagasaki University Hospital
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- KAMIO Yoshiyuki
- Department of Dermatology, Nagasaki University Hospital
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- NAKAMICHI Kazuo
- Department of Virology 1, National Institute of Infectious Diseases
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- YUKITAKE Motohiro
- Department of Neurology, Kouhoukai Takagi Hospital
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- IMAIZUMI Yoshitaka
- Department of Hematology, Nagasaki University Hospital
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- MIYAZAKI Yasushi
- Department of Hematology, Nagasaki University Hospital
Bibliographic Information
- Other Title
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- 菌状息肉症に合併した進行性多巣性白質脳症
- キンジョウ ソクニクショウ ニ ガッペイ シタ シンコウセイ タソウセイ ハクシツ ノウショウ
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Abstract
<p>A 58-year-old man was diagnosed with mycosis fungoides (MF) confirmed by skin biopsy for systemic erythema that appeared in 2006 and had been on psoralen plus ultraviolet A (PUVA) therapy and topical steroids. In September 2017, he had diffuse large B-cell lymphoma and received chemotherapy. Since March 2019, tumor stage MF with large cell transformation was observed, and chemotherapy containing brentuximab vedotin (BV) was performed, which yielded a remarkable response. During the preparation for allogeneic hematopoietic stem cell transplantation, bradykinesia, delayed response, and cognitive decline were observed. Head magnetic resonance imaging fluid-attenuated inversion recovery images showed hyperintensity in the deep white matter below the bilateral frontal cortex. The general cerebrospinal fluid test revealed no abnormalities and was below the sensitivity of JC virus (JCV) quantitative PCR. As progressive multifocal leukoencephalopathy (PML) was strongly suspected from clinical symptoms and radiographic signs, ultrasensitive JCV testing was performed. The test result was positive; hence, the patient was diagnosed with PML. Chemotherapy was discontinued, but his central nervous system symptoms worsened, and he died on the 135th day of illness. We considered that PML developed based on the underlying disease and immunodeficiency caused by chemotherapy such as BV.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 63 (3), 206-210, 2022
The Japanese Society of Hematology
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Details 詳細情報について
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- CRID
- 1390573242853832576
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- NII Book ID
- AN00252940
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 032102244
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- KAKEN
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- Abstract License Flag
- Disallowed