脳腫瘍の分子診断と2021WHO新分類

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  • Molecular Diagnosis of Brain Tumors and the 2021 WHO Classification
  • ノウ シュヨウ ノ ブンシ シンダン ト 2021WHO シン ブンルイ

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説明

The diagnosis of brain tumors has been historically made based on the tumor origin and histopathological features. The recent advance of molecular analysis of brain tumors has identified characteristic genetic alterations. Some of these alterations better determines biological features of tumors than histological diagnosis. Therefore, integrated diagnosis with histology and molecular data was introduced in 2016 WHO classification, which means that the diagnosis of the brain tumors cannot be possible without molecular diagnosis. The mutation of IDH and H3F3A, and chromosome 1p/19q deletion need to be determined for the integrated diagnosis. After 2016 classification, new molecular findings have been identified, and new diagnostic criteria with molecular data have been proposed. In this review, I will briefly review the history of the molecular diagnosis of glioma, and summarize general changes in the 2021 WHO new classification.

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