閾値未満の興奮性シナプス刺激が与えられた海馬ニューラルネットワークモデルにおける不規則なシナプスノイズによるθ-γ 位相振幅結合の生成

DOI Web Site
  • 森 亮介
    関東学院大学大学院工学研究科総合工学専攻
  • 簑 弘幸
    関東学院大学大学院工学研究科総合工学専攻

書誌事項

タイトル別名
  • Random Synaptic Noise Can Generate θ-γ Phase Amplitude Coupling in a Hippocampal Neural Network Model with Sub-threshold Excitable Synaptic Stimuli
  • イキチ ミマン ノ コウフンセイ シナプス シゲキ ガ アタエラレタ カイバ ニューラルネットワークモデル ニ オケル フキソク ナ シナプスノイズ ニ ヨル th-gイソウ シンプク ケツゴウ ノ セイセイ

この論文をさがす

抄録

<p>θ-γ phase-amplitude coupling (PAC) is observed in neural networks of the hippocampus, in which the amplitude of high-frequency oscillations, γ wave, is modulated by the phase of low-frequency oscillations—θ wave. Several studies have shown that the degree of PAC is closely related to memory formation. In contrast, the stochastic resonance (SR) phenomenon, in which the addition of random synaptic noise can enhance the transmission of sub-threshold synaptic stimuli, is also observed in the hippocampus. Although PAC reportedly appears in a specific status of brain activity, it is still unclear if and how random synaptic noise could contribute to generating θ-γ PAC. In this study, we investigated whether or not θ-γ PAC could be generated by an addition of random synaptic noise in a hippocampal neural network model with sub-threshold excitable synaptic stimuli using the modulation index (MI) through computer simulations. The results of computer simulations showed that the typical resonance curve of resonance phenomena, i.e., MI was maximized at a specific amplitude of synaptic noise. Therefore, it is concluded that θ-γ PAC can be generated by the vibrational mode transition, induced by the random synaptic noise, in the hippocampal neural network model with mixed sub-and supra-threshold stimuli.</p>

収録刊行物

  • 生体医工学

    生体医工学 60 (1), 32-37, 2022-03-10

    公益社団法人 日本生体医工学会

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ