Impact of Serum Zinc Level and Oral Zinc Supplementation on Clinical Outcomes in Patients Undergoing Infrainguinal Bypass for Chronic Limb-Threatening Ischemia
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- Kodama Akio
- Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya University School of Medicine
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- Komori Kimihiro
- Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya University School of Medicine
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- Koyama Akio
- Department of Vascular Surgery, Ichinomiya Municipal Hospital
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- Sato Tomohiro
- Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya University School of Medicine
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- Ikeda Shuta
- Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya University School of Medicine
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- Tsuruoka Takuya
- Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya University School of Medicine
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- Kawai Yohei
- Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya University School of Medicine
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- Niimi Kiyoaki
- Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya University School of Medicine
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- Sugimoto Masayuki
- Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya University School of Medicine
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- Banno Hiroshi
- Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya University School of Medicine
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- Nishida Kazuki
- Biostatistics and Bioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital
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説明
<p>Background: Zinc (Zn) has been reported to play an important role in wound healing (WH). Nevertheless, the effect of Zn in chronic limb-threatening ischemia (CLTI) patients is unclear. This study investigated the effect of Zn on the clinical outcomes of CLTI patients undergoing bypass surgery.</p><p>Methods and Results: This study reviewed 111 consecutive patients who underwent an infrainguinal bypass from 2012 to 2020. Patients with Zn deficiency (serum Zn level <60 μg/dL) received oral Zn supplementation and maintained a normal level until WH. This study aimed to explore: (1) the effect of Zn deficiency; and (2) Zn supplementation in Zn-deficient patients on the clinical outcomes of this cohort. Patients with Zn deficiency, Zn supplementation, and no Zn supplementation despite Zn deficiency accounted for 48, 21, and 42 patients, respectively. (1) Zn deficiency was associated with WH (HR, 0.47; 95% CI, 0.29–0.78: P=0.003), major adverse limb events (MALE) (HR, 2.53; 95% CI, 1.26–5.09: P=0.009), and major amputation or death (HR, 3.17; 95% CI, 1.51–6.63: P=0.002). (2) Zn supplementation was positively related to WH (HR, 2.30; 95% CI, 1.21–4.34: P=0.011). This result was confirmed using propensity score matching (HR, 2.24; 95% CI, 1.02–4.87: P=0.043).</p><p>Conclusions: The current study revealed that Zn level was associated with clinical outcomes in CLTI patients after bypass surgery. Oral Zn supplementation could improve WH in these patients.</p>
収録刊行物
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- Circulation Journal
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Circulation Journal 86 (6), 995-1006, 2022-05-25
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390573715167456896
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 032176654
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- PubMed
- 35342125
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可