Mitotic Index Reduction and Cytotoxic Effects of Leaf Aqueous Extract of <i>Maesa macrophylla</i> (Wall.) A. DC. in <i>Allium cepa</i> Root Tip Cells

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  • Barman Anuva
    Molecular Biology and Genetics Unit, Department of Zoology, The University of Burdwan
  • Ray Sanjib
    Molecular Biology and Genetics Unit, Department of Zoology, The University of Burdwan

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<p>Maesa macrophylla (Wall.) A. DC. is a traditionally used medicinal plant. The present study aimed to analyze the mitotic index reducing and cytotoxic potentials of the leaf aqueous extract of M. macrophylla (LAEMM) in Allium cepa root tip cells. The 48-h aged A. cepa roots were treated with LAEMM (0–4 mg mL−1) for 2–72 h and the root growth retardation (RGR), mitotic index (MI) reduction, and mitotic abnormalities (MAs) like sticky and vagrant chromosomes, anaphase bridge, polar deviation at metaphase or anaphase, etc. were analyzed. The LAEMM induced concentration and time-dependent RGR effects, MI reduction, and the formation of different types of MAs. Thus, the present work explored here cytotoxic effects of LAEMM in A. cepa root tip cells.</p>

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