Muscle-Specific Receptor Tyrosine-Kinase-Antibody-Positive Myasthenia Gravis Diagnosed as a Result of a Surgery-Induced Crisis：A Case Report

KOJIMA Mina, KOMATSU Satoshi, YATABE Tomoaki, KOMURA Hidefumi, NAKAMURA Tomoyuki, NISHIDA Osamu

doi:10.2199/jjsca.42.217

<p>This report presents a male patient in his 60s who was diagnosed with muscle-specific receptor tyrosine-kinase（MuSK） antibody-positive myasthenia gravis（MG） because of a surgery-induced crisis. This patient presented with difficulty stabilizing his neck and trunk. He was initially diagnosed with cervical spondylotic myelopathy, but that diagnosis did not account for his current symptoms. Due to disturbances in his gait, a laminoplasty was performed early on in his treatment. On the eleventh day following surgery, the patient suffered cardiopulmonary arrest due to respiratory arrest and was admitted to the intensive care unit after being resuscitated. The patient tested positive for MuSK antibodies and was subsequently diagnosed with MG. He was administered immunoglobulin therapy, blood purification therapy and steroids before being transferred to a different hospital 79 days after surgery under non-invasive positive pressure ventilation. MuSK antibody-positive MG develops rapidly and the risk of crisis is high. In addition, this disease can be difficult to diagnose.</p>

Muscle-Specific Receptor Tyrosine-Kinase-Antibody-Positive Myasthenia Gravis Diagnosed as a Result of a Surgery-Induced Crisis：A Case Report

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