トレーサー測定法を用いたバナジウムおよび亜鉛を投与したラットにおける血中動態解析
書誌事項
- タイトル別名
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- Pharmacokinetic study on gastrointestinal absorption and disposition in the blood of <sup>48</sup>vanadium and <sup>65</sup>zinc in healthy rats using radiotracer method
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説明
<p>In recent years, vanadium and zinc compounds are demonstrated to exhibit insulinomimetic effects in in vitro and in vivo experiments, and to treat both insulin-dependent typel and insulin-independent type 2 diabetes mellitus. We have reported that vanadyl complexes normalize the blood glucose level of streptozotocin-induced type 1 diabetic rats, and that zinc complexes decrease the blood glucose level of hereditary type 2 GK rats. To understand the action mechanism of vanadium and zinc treatment, in this study, we focused on investigating pharmacokinetics on gastrointestinal absorption and disposition in the blood of vanadium and zinc ions in healthy rats by administration of their radiotracers. Clearance curves of 48V in the blood of rats receiving intravenous injection of vanadyl (48VO2+) and vanadate (48VO43-) ions were not significantly different in spite of administration of the different oxidation state and chemical species of vanadium, because of rapid reduction of vanadate to vanadyl in the blood and organs of rats. On the other hand, absorption of 48VO43- was found to be 3 fold higher than that of 48VO2+, suggesting the chemical species-dependent mechanism on the gastrointestinal absorption of vanadium. Bioavailability of 65Zn was estimated to be 0.27, which coincides well with the result in rats given non-tracer ZnCl2, strongly indicating the need to develop zinc complexes with higher bioavailability exhibiting more hypoglycemic activity than zinc ion.</p>
収録刊行物
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- 微量栄養素研究
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微量栄養素研究 20 (0), 5-8, 2003-12-20
日本微量栄養素学会
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詳細情報 詳細情報について
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- CRID
- 1390574268847853184
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- ISSN
- 24366617
- 13462334
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- 抄録ライセンスフラグ
- 使用可