Association between <i>mu opioid receptor</i> gene polymorphisms and alcohol dependence in a Japanese population

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  • MIKAMI Marina
    Laboratory of Physiology (Project of Neurophysiology), Course of Environmental Health Science, Graduate School of Environmental Health, Azabu University
  • KONGO Sakyo
    Laboratory of Physiology (Project of Neurophysiology), Course of Environmental Health Science, Graduate School of Environmental Health, Azabu University
  • AOKI Rie
    Laboratory of Physiology (Project of Neurophysiology), Course of Environmental Health Science, Graduate School of Environmental Health, Azabu University
  • KAWAI Atsuko
    Koutokukai Total Health Clinic
  • NISHIZAWA Daisuke
    Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science
  • IKEDA Kazutaka
    Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science
  • ONOZAWA Yuya
    Laboratory of Physiology, Azabu University
  • IWAHASHI Kazuhiko
    Laboratory of Physiology (Project of Neurophysiology), Course of Environmental Health Science, Graduate School of Environmental Health, Azabu University Laboratory of Physiology, Azabu University Health Administration Center, Azabu University

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Other Title
  • 日本人におけるミューオピオイド受容体遺伝子多型とアルコール依存症の関連研究
  • Association between mu opioid receptor gene polymorphisms and alcohol dependence in a Japanese population

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Abstract

<p>Alcohol dependence is an addiction that causes psychological and physical dependence and makes it difficult for those affected to control their intake of alcohol. The μ (mu), δ (delta) and κ (kappa) opioid receptors are thought to be associated with the development of alcohol dependence. Research has shown that μ opioid receptor knockout mice exhibit reduced alcohol consumption and reduced preference for alcohol. In this study, we confirmed whether mu opioid receptor (OPRM1) polymorphisms (IVS2+691C/G, −172G/T and −1748G/A) indeed have an effect on alcohol dependence formation in 64 patients, with 73 healthy people used as a control group. We compared the genotype, allele, carrier (minor allele carriers versus major allele homozygous carriers) and haplotype frequencies between these groups. In addition, the 1510A allele of acetaldehyde dehydrogenase 2 (ALDH2) polymorphism (1510G/A) causes poor metabolism of acetaldehyde, a major metabolite of alcohol. We also focused on ALDH2 1510G/G (ALDH2 *1/*1) carriers in the subjects. Three OPRM1 and one ALDH2 genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. No significant differences were found in the frequency of OPRM1 polymorphisms between those suffering from alcohol dependence and the control group. We concluded that the three OPRM1 polymorphisms (IVS2+691C/G, −172G/T and −1748G/A) were not likely to be risk factors for alcohol dependence in a Japanese population. This report is the first in a Japanese population. Nevertheless, further analysis of the opioid receptor gene in a large sample size is required.</p>

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