Efficacy of Combination Chemotherapy of Gemcitabine and Nedaplatin for Squamous Cell Carcinoma of the Urinary Tract : Experience of Four Cases

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  • 尿路扁平上皮癌に対するゲムシタビン/ネダプラチン療法の有効性 : 4例の経験
  • ニョウロ ヘンペイ ジョウヒ ガン ニ タイスル ゲムシタビン/ネダプラチン リョウホウ ノ ユウコウセイ : 4レイ ノ ケイケン

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Abstract

We report the use of combination chemotherapy of gemcitabine (800 mg/m² on day1 and 8) and nedaplatin (60 mg/m² on day 1), including neoadjuvant therapy in four cases of squamous cell carcinoma of the urinary tract. In each case, the dose was reduced after assessing the performance status and renal function of the patient. Among the four cases, the best overall outcome was complete response in one case, partial response in two cases, and stable disease in one case. The main adverse event observed was thrombocytopenia; however, no serious adverse events were observed, and this regimen was safely administered. Therefore, we believe that this regimen could be an effective treatment option for progressive squamous cell carcinoma originating from the urinary tract.

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  • 泌尿器科紀要

    泌尿器科紀要 68 (6), 191-196, 2022-06-30

    泌尿器科紀要刊行会

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