Evaluation of the Correlation between Functional Positions of Hydrophilic Group and Porphyrin Accumulation in Cancer Cells

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  • TOJO Toshifumi
    Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
  • KURAHASHI Kakeru
    Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
  • KONDO Takeshi
    Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
  • YUASA Makoto
    Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science

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  • 親水性官能基の修飾位置とポルフィリンのがん細胞集積性の相関関係

Abstract

<p>Porphyrin, which forms the basic skeleton of important colour materials (hem, chlorophyll,etc.) shows the ability to accumulate in vivo in cancer cells. While the discovery of new functional molecules for application of photodynamic therapy and drug delivery systems has been actively researched, the effect of functional porphyrin positions has not been investigated. In this study, we evaluated the accumulation in cancer cells of porphyrin containing a hydrophilic functional group (polyethylene glycol), and found that the hydrophilicity of the functional group and its position in porphyrin affected the accumulation.</p>

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