Targeting intrinsically disordered proteins as drug targets: perspective and problems

DOI

Bibliographic Information

Other Title
  • 天然変性タンパク質を標的とした創薬　～その可能性と課題～

Abstract

Intrinsically disordered protein (IDP) is a polypeptide that does not adopt a compact fold under a physiological condition. It tends to be appeared at the hub position in the intracellular protein-protein network, thereby considered as an attractive drug target. Recently, many examples of IDPs’ implication in liquid-liquid phase separation (LLPS) have also emerged. Nevertheless, targeting IDP sounds still difficult, because the lack of highly accurate three-dimensional structure of IDP may hamper application of many modern structure-guided drug design and discovery techniques. Only the solution NMR based strategy, but not either the X-ray crystallography or cryo-electron microscopy, is available to solve the structure of IDP for further virtual screening.

Journal

  • MEDCHEM NEWS

    MEDCHEM NEWS 32 (3), 136-139, 2022-08-01

    The Pharmaceutical Society of Japan

Keywords

Details 詳細情報について

  • CRID
    1390574411905896320
  • DOI
    10.14894/medchem.32.3_136
  • ISSN
    24328626
    24328618
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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