Targeting intrinsically disordered proteins as drug targets: perspective and problems
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- Hiroaki Hidekazu
- Graduate School of Pharmaceutical Sciences, Nagoya University
Bibliographic Information
- Other Title
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- 天然変性タンパク質を標的とした創薬 ~その可能性と課題~
Description
Intrinsically disordered protein (IDP) is a polypeptide that does not adopt a compact fold under a physiological condition. It tends to be appeared at the hub position in the intracellular protein-protein network, thereby considered as an attractive drug target. Recently, many examples of IDPs’ implication in liquid-liquid phase separation (LLPS) have also emerged. Nevertheless, targeting IDP sounds still difficult, because the lack of highly accurate three-dimensional structure of IDP may hamper application of many modern structure-guided drug design and discovery techniques. Only the solution NMR based strategy, but not either the X-ray crystallography or cryo-electron microscopy, is available to solve the structure of IDP for further virtual screening.
Journal
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- MEDCHEM NEWS
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MEDCHEM NEWS 32 (3), 136-139, 2022-08-01
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390574411905896320
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- ISSN
- 24328626
- 24328618
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed