Effect of Aging on Skeletal Muscle Regeneration in Rats

DOI Web Site 11 References
  • NISHIDA Ryoichi
    Division of Rehabilitation, Takanohara Central Hospital Division of Health Science, Graduate School of Health Science, Kio University
  • GOTOH Jun
    Department of Anatomy and Cell Biology, Graduate School of Medicine, Osaka City University Division of Health Science, Graduate School of Health Science, Kio University
  • KAMAJIRI Noboru
    Division of Rehabilitation, Kishiwada Rehabilitation Hospital
  • FUJITA Takumi
    Division of Rehabilitation, Yagi Neurosurgical Hospital
  • TERAYAMA Shogo
    Division of Rehabilitation, Moeginomura Division of Health Science, Graduate School of Health Science, Kio University
  • SHIRAHASE Mimo
    Division of Rehabilitation, Kashiba Asahigaoka Hospital Division of Health Science, Graduate School of Health Science, Kio University
  • OKADA Keisuke
    Division of Rehabilitation, Kashiba Seiki Hospital Division of Health Science, Graduate School of Health Science, Kio University
  • IMAGITA Hidetaka
    Division of Health Science, Graduate School of Health Science, Kio University

Bibliographic Information

Other Title
  • 加齢が骨格筋再生に与える影響
  • ─ラットでの研究結果から─

Abstract

<p>[Purpose] This study investigated the effect of aging on muscle regeneration in rats. [Participants and Methods] Male Wistar rats were divided into 3 groups of 10-week-old, 24-week-old, and 95-week-old animals. We administered a cardiotoxin to the soleus of the rats to create a skeletal muscle injury model, and physiological analysis and histological analysis was performed at 1, 2, 4, 7, 14, 28 days after cardiotoxin administration. [Results] The cross-sectional area of the injured skeletal muscle increased over time in all of the groups, but it was observed earlier in the younger groups. The number of Pax7 positive cells peaked in the 10-week-old- and 24-week-old groups on day 4 after cardiotoxin administration, but the peak was delayed in the 95-week-old group. [Conclusion] The results suggest that skeletal muscle hypertrophy and the number of muscle satellite cells expressed decreases with aging.</p>

Journal

  • Rigakuryoho Kagaku

    Rigakuryoho Kagaku 37 (4), 383-386, 2022

    The Society of Physical Therapy Science

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