Changes in the Pathogenicity of SARS-CoV-2 According to Waves

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  • 新型コロナウイルスの病原性の経時的変化に関する単施設観察研究
  • シンガタ コロナウイルス ノ ビョウゲンセイ ノ ケイジテキ ヘンカ ニ カンスル タンシセツ カンサツ ケンキュウ

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Abstract

The pathogenicity of SARS-CoV-2 has changed as the virus mutates, with some variants causing waves of new infections. We investigated the pathogenic changes in the virus during waves 3, 4, and 5 in terms of severity, treatment methods, and outcomes in 208 patients with COVID-19 admitted to our hospital. Maximum severity during hospitalization tended to increase in patients with moderate I and II COVID-19 during waves 4 and 5; however, the number of severe cases decreased. Comparison by propensity score matching revealed that the number of patients with moderate I and II COVID-19 also increased significantly during wave 5.

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