Chronic Pain Research Using Human Peripheral Blood-induced Microglia-like Cells

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  • Ohgidani Masahiro
    Asahikawa Medical University, Department of Functional Anatomy and Neuroscience Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyusyu University
  • A. Kato Takahiro
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyusyu University Multidisciplinary Pain Center, Kyushu University Hospital
  • Hosoi Masako
    Multidisciplinary Pain Center, Kyushu University Hospital Department of Psychosomatic Medicine, Kyushu University Hospital

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Other Title
  • ヒト末梢血誘導型ミクログリア細胞技術を用いた慢性疼痛研究
  • ヒト マッショウケツ ユウドウガタ ミクログリア サイボウ ギジュツ オ モチイタ マンセイ トウツウ ケンキュウ

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<p>Microglia, a type of brain cell, respond rapidly to minute environmental changes and function as the center of the immune response in the brain by phagocytosis and cytokine production. Their dysfunction and abnormal activation have been suggested to be involved in various pathological conditions. Chronic pain is a multifaceted disease unique to humans. Therefore, it is necessary to conduct experiments using human cells. However, these hurdles were incredibly high. We successfully developed a technique to generate induced microglia-like cells (iMG cells) from monocytes in the peripheral blood. iMG cells can be generated by adding two cytokines, GM-CSF and IL-34, to monocytes and culturing them for 2 weeks. Unlike iPS cells, iMG cells can be produced by chemical induction without genetic recombination, making them simple, safe, and easy to produce in clinical facilities. We have previously reported microglial abnormalities in diseases such as Nasu-Hakola disease and bipolar disorder using iMG cells. In this presentation, we report our results on the utility and potential of our iMG cells as a translational research tool and actual translational studies in fibromyalgia.</p>

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