Dynamic Molecular Science Explored with Cinematographic Molecular Imaging
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- Harano Koji
- 物質・材料研究機構 先端材料解析研究拠点
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- Nakamuro Takayuki
- 東京大学 大学院理学系研究科化学専攻
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- Nakamura Eiichi
- 東京大学 大学院理学系研究科化学専攻
Bibliographic Information
- Other Title
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- 分子映像によって開拓する動的分子科学の新しい世界
Description
<p>Single-molecule atomic-resolution time-resolved electron microcopy (SMART-EM) with a high-speed, high-resolution transmission electron microscope has ushered in the era of “cinematic molecular science,” in which the dynamic behavior of organic and inorganic molecules can be studied through real-time video images. High speed imaging without increase of electron dose results in very low electron dose per frame, which often causes a very low signal to noise ratio. We have established a method to improve the image quality optimized for SMART-EM by applying the Chambolle Total Variation denoising, which enables tracking of molecular motion with sub-millisecond temporal resolution and sub-angstrom localization precision. Herein we demonstrate in-situ observation of a nanomechanical shuttling motion of a single molecule and an atomic-level crystallization process as applications of the high-speed SMART-EM. We also introduce a new molecular model, atomic number correlated (ZC) molecular model, designed for spreading the microscopic molecular imaging to chemists who are still unfamiliar to electron microscopy.</p>
Journal
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- KENBIKYO
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KENBIKYO 57 (2), 59-64, 2022-08-30
The Japanese Society of Microscopy
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Keywords
Details 詳細情報について
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- CRID
- 1390574809776524416
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- ISSN
- 24342386
- 13490958
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed