Dynamic Molecular Science Explored with Cinematographic Molecular Imaging

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  • 分子映像によって開拓する動的分子科学の新しい世界

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<p>Single-molecule atomic-resolution time-resolved electron microcopy (SMART-EM) with a high-speed, high-resolution transmission electron microscope has ushered in the era of “cinematic molecular science,” in which the dynamic behavior of organic and inorganic molecules can be studied through real-time video images. High speed imaging without increase of electron dose results in very low electron dose per frame, which often causes a very low signal to noise ratio. We have established a method to improve the image quality optimized for SMART-EM by applying the Chambolle Total Variation denoising, which enables tracking of molecular motion with sub-millisecond temporal resolution and sub-angstrom localization precision. Herein we demonstrate in-situ observation of a nanomechanical shuttling motion of a single molecule and an atomic-level crystallization process as applications of the high-speed SMART-EM. We also introduce a new molecular model, atomic number correlated (ZC) molecular model, designed for spreading the microscopic molecular imaging to chemists who are still unfamiliar to electron microscopy.</p>

Journal

  • KENBIKYO

    KENBIKYO 57 (2), 59-64, 2022-08-30

    The Japanese Society of Microscopy

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