Dynamic Molecular Science Explored with Cinematographic Molecular Imaging

Harano Koji, Nakamuro Takayuki, Nakamura Eiichi

doi:10.11410/kenbikyo.57.2_59

<p>Single-molecule atomic-resolution time-resolved electron microcopy (SMART-EM) with a high-speed, high-resolution transmission electron microscope has ushered in the era of “cinematic molecular science,” in which the dynamic behavior of organic and inorganic molecules can be studied through real-time video images. High speed imaging without increase of electron dose results in very low electron dose per frame, which often causes a very low signal to noise ratio. We have established a method to improve the image quality optimized for SMART-EM by applying the Chambolle Total Variation denoising, which enables tracking of molecular motion with sub-millisecond temporal resolution and sub-angstrom localization precision. Herein we demonstrate in-situ observation of a nanomechanical shuttling motion of a single molecule and an atomic-level crystallization process as applications of the high-speed SMART-EM. We also introduce a new molecular model, atomic number correlated (ZC) molecular model, designed for spreading the microscopic molecular imaging to chemists who are still unfamiliar to electron microscopy.</p>

Dynamic Molecular Science Explored with Cinematographic Molecular Imaging

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