Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia
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- Kawano Noriaki
- Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
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- Nakamura Shunou
- Department of Dermatology, Faculty of Medicine, University of Miyazaki, Japan
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- Mochida Kousuke
- Department of Dermatology, Faculty of Medicine, University of Miyazaki, Japan
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- Yoshida Shuro
- Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
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- Kuriyama Takuro
- Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
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- Nakaike Takashi
- Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
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- Shimokawa Tomonori
- Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
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- Tochigi Taro
- Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
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- Yamashita Kiyoshi
- Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
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- Mashiba Koichi
- Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
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- Kikuchi Ikuo
- Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
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- Takarabe Aina
- Department of Dermatology, Miyazaki Prefectural Miyazaki Hospital, Japan
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- Moriguchi Sayaka
- Department of Pathology, Miyazaki Prefectural Miyazaki Hospital, Japan
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- Mori Yasuo
- Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Japan
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- Takenaka Katsuto
- Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Japan
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- Shimoda Kazuya
- Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Japan
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- Ochiai Hidenobu
- Trauma and Critical Care Center, Faculty of Medicine, University of Miyazaki, Japan
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- Amano Masahiro
- Department of Dermatology, Faculty of Medicine, University of Miyazaki, Japan
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説明
<p>Secondary malignancies that develop after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) have become serious issues. A 47-year-old man who developed acute myeloid leukemia in 2009 and subsequently underwent allo-HSCT twice: in 2009 and 2011. In 2015, voriconazole for lung aspergillus was started. In 2018, chronic graft-versus-host disease (GVHD) and multiple actinic keratoses manifested at his head. In 2020, some lesions were diagnosed as squamous cell carcinoma, so voriconazole was withdrawn, and subsequent surgery and radiation led to remission. Long-term administration of voriconazole in addition to allo-HSCT and chronic GVHD may be closely related to secondary skin cancer. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 61 (18), 2771-2774, 2022-09-15
一般社団法人 日本内科学会
