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Surface CD3-negative monomorphic epitheliotropic intestinal T-cell lymphoma
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- Domoto Hideharu
- Department of Diagnostic Pathology, Keiyu Hospital, Yokohama, Kanagawa, Japan,
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- Araki Takahiro
- Department of Hematology, Keiyu Hospital, Yokohama, Kanagawa, Japan,
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- Ogai Asuka
- Department of Hematology, Keiyu Hospital, Yokohama, Kanagawa, Japan,
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- Inukai Michiko
- Department of Surgery, Keiyu Hospital, Yokohama, Kanagawa, Japan,
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- Chen Chien K
- Department of Hematology, Keiyu Hospital, Yokohama, Kanagawa, Japan,
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- Tomita Sakura
- Department of Pathological Diagnostics, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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- Mukai Kiyoshi
- Department of Diagnostic Pathology, Keiyu Hospital, Yokohama, Kanagawa, Japan,
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- Nakamura Naoya
- Department of Pathological Diagnostics, Tokai University School of Medicine, Isehara, Kanagawa, Japan
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Description
<p>Intestinal T/NK-cell lymphomas include enteropathy-associated T-cell lymphoma (EATL), monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), indolent T-cell lymphoproliferative disorders of the GI tract (ITCLPD), extranodal NK/T-cell lymphoma, nasal type (ENKTL), and intestinal T-cell lymphoma NOS (ITCL-NOS). Here we describe a case of surface CD3-negative MEITL. A 63-year-old Japanese female had a tumor located in the conglomerated ileum, which formed multiple mass lesions. The resected tissue showed a diffuse infiltration of monomorphic medium-sized lymphocytes with epitheliotropism. Flowcytometry using a fresh specimen of the tumor revealed positivity for CD7, CD8, CD38, and CD56, but not surface CD3. On immunohistochemistry, the tumor showed positivity for cytoplasmic CD3, CD8, CD56, TIA-1, Granzyme B, and perforin. EBER with in situ hybridization was negative. Moreover, H3K36me3, which is negative in MEITL with SETD2-mutation, was positive. This is an important case of MEITL due to its oncogenesis.</p>
Journal
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 62 (3), 169-174, 2022
Japanese Society of Lymphoma Research