The current situation and perspectives of mRNA delivery to the kidney
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- Kawaguchi Maho
- Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University
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- Kato Naoya
- Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University
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- Kamiya Mariko
- Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University
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- Mukai Hidefumi
- Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University
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- Kawakami Shigeru
- Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University
Bibliographic Information
- Other Title
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- 腎臓に対するmRNAデリバリーの現状と今後の展望
Abstract
For mRNA delivery to the kidney, the choice of administration route and vector is very important due to the structural characteristics of the kidney. Furthermore, it is necessary to devise a combination of physical methods to improve the transduction efficiency. The transfeted cells depend on the delivery methods. Therefore, it may be useful to identify the transfected cells and evaluate their expression distribution in the development of therapeutic strategies. Since there are few reports in the field of mRNA delivery to the kidney, this review describes gene/nucleic acid delivery, focusing on administration routes and vectors, and introduces mRNA delivery to the kidney.
Journal
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- Drug Delivery System
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Drug Delivery System 37 (3), 253-262, 2022-07-25
THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM
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Details 詳細情報について
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- CRID
- 1390575340765633024
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- ISSN
- 18812732
- 09135006
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- KAKEN
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- Abstract License Flag
- Disallowed