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- 和田 守正
- 長崎国際大学
書誌事項
- タイトル別名
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- Role of ABC Transporters in Cancer Development and Malignant Alteration
- ガン ノ ハッセイ ト アクセイカ ニ オケル ABC トランスポーター ノ ヤクワリ
この論文をさがす
説明
<p>ATP-binding cassette (ABC) transporters, which comprise the largest gene-family in humans, are membrane proteins that transport various substrates, depending on ATP hydrolysis. Among these transporters, several include ABCB1 (P-glycoprotein), identified here for the first time in humans, which exports anti-cancer drugs from cancer cells, thus participating in multidrug resistance (MDR). ABC transporters also export drugs, in general, from the human body, therefore affecting overall pharmacokinetics. We have contributed, here, to a better understanding of the role of these exporter proteins in two aspects. First, we have cloned the human ABCC2 gene and identified mutations in hereditary hyperbilirubinemia patients, demonstrating the role of ABCC2 as a xenobiotic export pump. Second, we also found an unexpected role of ABCB1 in cancer, in that it promotes tumor initiation independently of the MDR phenomenon, which was further confirmed by a chemoprevention experiment using verapamil, an ABCB1 inhibitor. In this review, I discuss the role of ABC transporters, both in biodefense against xenobiotics and in cancer development and malignant alterations, based on our results as well as the studies of others.</p>
収録刊行物
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- 薬学雑誌
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薬学雑誌 142 (11), 1201-1225, 2022-11-01
公益社団法人 日本薬学会