Radiation-induced Brain Calcification Leads to L-dopa-resistant Parkinsonism and Cerebellar Ataxia

  • Shimada Tomoyo
    Department of Neurology, Juntendo University School of Medicine, Japan
  • Kamo Ryota
    Department of Neurology, Juntendo University School of Medicine, Japan
  • Daida Kensuke
    Department of Neurology, Juntendo University School of Medicine, Japan
  • Nishioka Kenya
    Department of Neurology, Juntendo University School of Medicine, Japan
  • Hattori Nobutaka
    Department of Neurology, Juntendo University School of Medicine, Japan
  • Tsunemi Taiji
    Department of Neurology, Juntendo University School of Medicine, Japan

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説明

<p>We experienced a young patient who presented with progressive parkinsonism and cerebellar ataxia. Brain magnetic resonance imaging revealed progressive brain calcification, expanding from the bilateral basal ganglia to the central pons, caused by a delayed reaction to the radiation therapy that she had received to treat craniopharyngioma 14 years earlier. Heterogeneous clinical symptoms due to radiation-induced brain calcification have been described, but parkinsonism has never been reported. While dopamine transporter-single photon emission computed tomography revealed only slight damage to the dopaminergic striatal pathway, the extension of calcification to the periventricular white matter was likely responsible for her parkinsonism. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 61 (24), 3723-3727, 2022-12-15

    一般社団法人 日本内科学会

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