Study on Biological Defense Function though Regulation of Drug Metabolism System by Food Factors

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  • Kitakaze Tomoya
    Department of Applied Biological Chemistry, Graduate School of Agriculture, Osaka Metropolitan University

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Other Title
  • 食品因子の薬物代謝系を介した生体防御機能に関する研究
  • (JSNFS Award for Young Investigators (2022))
  • (令和4年度日本栄養・食糧学会奨励賞受賞)

Abstract

<p>Toxicological effects of polycyclic aromatic hydrocarbons (PAHs) are mediated mainly by the aryl hydrocarbon receptor (AhR). Therefore, reduction of AhR activity is a promising strategy for prevention of xenobiotic-induced toxicity. Activation of nuclear factor-erythroid 2-related factor 2 (Nrf2) results in enhanced antioxidant capacity and protection against environmental stressors by inducing phase II drug-metabolizing enzymes. The author revealed that luteolin and kaempferol coordinately prevent AhR-induced phase I drug-metabolizing enzyme, and a physiological concentration of luteolin, achievable from dietary consumption, activated Nrf2. Moreover, B[a]P-induced AhR activation caused lipid accumulation in the liver through circadian disruption; however, luteolin and kaempferol inhibited the circadian disruption caused by AhR activation. These results indicate that luteolin and kaempferol enhance biological defense function against xenobiotic-induced toxicity through the regulation of the drug metabolism system.</p>

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