書誌事項
- タイトル別名
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- BQ788, a selective ET<sub>B</sub> receptor antagonist alleviates inflammatory reactions after traumatic brain injury in mice
説明
<p>Traumatic brain injury (TBI) is a fetal damage to the brain resulted from an external force to head by accidents and falls. One of the TBI-induced severe pathogenesis is an inflammatory damage. We previously suggested that BQ788, an endothelin ETB receptor antagonist alleviated blood-brain barrier disruption and brain edema in TBI mice. In this study, we investigated the effects of BQ788 on inflammatory reactions in TBI mice. As a model of TBI, a fluid percussion injury (FPI) was performed by a hydraulic impact on the mouse dura mater. BQ788 (15 nmol/day) was repeatedly administrated into lateral cerebroventricle from 2 to 5 days after FPI. As a maker of neutrophil, myeloperoxidase (MPO) and Ly6G were examined by fluorescent immunostaining. Expressions of inflammatory cytokines (tumor necrosis factor-α: TNF-α and interleukin-1β: IL-1β) and chemokines (monocyte chemoattractant protein−1: MCP−1 and mouse macrophage inflammatory protein-2: MIP-2) were measured by Real-time PCR. After FPI, MPO- and Ly6G-posotive cells were increased in the mouse cerebrum. Administration of BQ788 decreased these positive cells. Additionally, BQ788 decreased FPI-induced increases in expressions of TNF-α, IL-1β, MCP-1 and MIP-2 in the mouse cerebrum. These results suggest that ETB receptor antagonist alleviates TBI-induced inflammatory reactions.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 96 (0), 2-B-P-093-, 2022
公益社団法人 日本薬理学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390576037462326144
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可