動物モデルを用いた超音波曝露の情動への影響の検討

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  • Investigating the effects of ultrasound exposure on emotion using animal models

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<p>Recently, ultrasound exposure has been shown to be a noninvasive method for modulating brain activity and has to be applied to treat mental disorders, such as depression. However, its underlying mechanism remains unclear. Therefore, there is a need for animal models that can investigate the mechanism of ultrasound exposure. In this study, we utilized olfactory bulbectomized (OB) rats as an animal model of depression and investigated their emotional state following ultrasound exposure. As a result, following exposure to high-frequency ultrasonic vocalizations (USV)s of rats, the hyperemotionality of OB rats was significantly suppressed. Also, USV exposure significantly reduced the latency to the first entry into the open arm in the elevated plus maze tests and the plasma corticosterone levels of OB rats. Furthermore, artificial ultrasounds (50 and 100 kHz) also significantly decreased the hyperemotionality score of OB rats. These results suggested that ultrasound exposure, regardless of vocal or artificial sound, ameliorated depressive-like behavior and stress level in OB rats. We proposed that OB rats might be an appropriate animal model to identify mechanisms underlying the effects of ultrasound exposure.</p>

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