逐次抽出法による畜水産物の筋肉および牛乳中の残留動物用医薬品のLC-MS/MS一斉分析法

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  • LC-MS/MS method for simultaneous determination of veterinary drugs in muscle of animal and fishery products and milk using sequential extraction
  • チクジ チュウシュツホウ ニ ヨル チクスイサンブツ ノ キンニク オヨビ ギュウニュウ チュウ ノ ザンリュウ ドウブツヨウ イヤクヒン ノ LC-MS/MS イッセイ ブンセキホウ

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We developed a simultaneous LC-MS/MS determination method for veterinary drugs in muscle of animal and fishery products and milk using sequential extraction with an organic solvent and buffer solution. To enhance the extraction efficiency of both the chelating compound and the hydrophobic compound, freeze ground samples were extracted first with an acetonitrile-methanol (1:1) solution and then with the buffer solution (pH 4.0). The extracts were combined after purification using a hexane/SPE cartridge column. Analytical validations for 65 compounds were done with salmon, shrimp, cattle muscle and milk. The accuracy and precision were within the required ranges of Japanese validation guidelines for a wide range of veterinary drugs (58 compounds in salmon, 51 compounds in shrimp, 63 compounds in cattle muscle, and 63 compounds in milk).

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