Quercetin up-regulates the expression of tumor-suppressive microRNAs in human cervical cancer

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  • MURATA Motoki
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka Nishi-ku Fukuoka 819-0395, Japan Advanced Research Support Center (ADRES), Ehime University, 10-13 Dogo-himata, Matsuyama, Ehime 790-8577, Japan
  • KOMATSU Satomi
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka Nishi-ku Fukuoka 819-0395, Japan
  • MIYAMOTO Emi
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka Nishi-ku Fukuoka 819-0395, Japan
  • OKA Chihiro
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka Nishi-ku Fukuoka 819-0395, Japan
  • LIN Ichian
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka Nishi-ku Fukuoka 819-0395, Japan
  • KUMAZOE Motofumi
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka Nishi-ku Fukuoka 819-0395, Japan
  • YAMASHITA Shuya
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka Nishi-ku Fukuoka 819-0395, Japan
  • FUJIMURA Yoshinori
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka Nishi-ku Fukuoka 819-0395, Japan
  • TACHIBANA Hirofumi
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 744 Motooka Nishi-ku Fukuoka 819-0395, Japan

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<p>Quercetin, a flavonol present in many vegetables and fruits, has been identified as a chemoprevention agent in several cancer models. However, the molecular mechanism of quercetin’s anticancer activity is not entirely understood. MicroRNAs (miRNAs), small noncoding RNAs, have been reported to play key roles in various biological processes by regulating their target genes. We hypothesized that quercetin can exert an anticancer effect through the regulation of miRNAs. To test this hypothesis, we investigated the effects of quercetin on the expression of tumor-suppressive miRNAs in cervical cancer. Quercetin up-regulated the in vivo and in vitro expression of tumor-suppressive miRNAs miR-26b, miR-126, and miR-320a. Quercetin suppressed the level of β-catenin, encoded by catenin beta 1 (CTNNB1), by up-regulating miR-320a in HeLa cells. Moreover, quercetin increased the expression of mir-26b, mir-126, and mir-320a precursors in HeLa cells. The results from this study show that quercetin has the potential to prevent cervical cancer by regulating the expression of tumor-suppressive miRNAs.</p>

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