Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus
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- Hosogi Shigekuni
- Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine Graduate School of Medical Science Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University
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- KUWAHARA Atsukazu
- Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine Graduate School of Medical Science Research Unit for Epithelial Physiology, Research Organization of Science and Technology, Ritsumeikan University Faculty of Education, Art and Science, Yamagata University
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- KUWAHARA Yuko
- Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine Graduate School of Medical Science Research Unit for Epithelial Physiology, Research Organization of Science and Technology, Ritsumeikan University
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- TANAKA Saori
- Department of Pharmacotherapeutics, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University
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- SHIMAMOTO Chikao
- Department of Pharmacotherapeutics, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University
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- TAGAWA Noriko
- Department of Medical Biochemistry, Kobe Pharmaceutical University
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- KATO Ikuo
- Department of Medical Biochemistry, Kobe Pharmaceutical University
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- YOSHIMOTO Kanji
- Department of Food Sciences and Biotechnology, Graduate School of Science and Technology, Hiroshima Institute of Technology Medical Research Institute, Kyoto Industrial Health Association
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- AOI Wataru
- Laboratory of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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- TAKATA Kazuyuki
- Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University
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- MIYAZAKI Hiroaki
- Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine Graduate School of Medical Science Department of Life Science, Faculty of Science and Engineering, Setsunan University
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- NIISATO Naomi
- Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine Graduate School of Medical Science Medical Research Institute, Kyoto Industrial Health Association Department of Health and Sports Sciences, Faculty of Health and Medical Sciences, Kyoto University of Advanced Science
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- TSUBO Yasuhiro
- Medical Research Institute, Kyoto Industrial Health Association College of Information Science and Engineering, Ritsumeikan University
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- YAGI Katsumi
- Medical Research Institute, Kyoto Industrial Health Association
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- NAKAHARI Takashi
- Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine Graduate School of Medical Science Research Unit for Epithelial Physiology, Research Organization of Science and Technology, Ritsumeikan University Medical Research Institute, Kyoto Industrial Health Association
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- MARUNAKA Yoshinori
- Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine Graduate School of Medical Science Research Unit for Epithelial Physiology, Research Organization of Science and Technology, Ritsumeikan University Medical Research Institute, Kyoto Industrial Health Association
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Abstract
<p>The present study tried to clarify if mumefural would prevent hyperglycemia, one of the typical symptoms of type 2 diabetes mellitus (T2DM), since mumefural is an extract from Japanese apricots preventing hyperglycemia. To clarify if mumefural would prevent T2DM pathogenesis, we used Otsuka Long-Evans Tokushima fatty (OLETF) rats, T2DM model. Mumefural diminished hyperglycemia, HOMA-IR and plasma triglyceride concentration in OLETF rats under fasting conditions. In addition, mumefural elevated protein expression of sodium-coupled monocarboxylate transporter 1 (SMCT1) in the distal colon participating in absorption of weak organic acids, which behave as bases but not acids after absorption into the body. Mumefural also increased the interstitial fluid pH around the brain hippocampus lowered in OLETF rats compared with non-T2DM LETO rats used as control for OLETF rats. Amyloid-beta accumulation in the brain decreased in accordance with the pH elevation. On the one hand, mumefural didn’t affect plasma concentrations of glucagon, GLP-1, GIP or PYY under fasting conditions. Taken together, these observations indicate that: 1) mumefural would be a useful functional food improving hyperglycemia, insulin resistance and the lowered interstitial fluid pH in T2DM; 2) the interstitial fluid pH would be one of key factors influencing the accumulation of amyloid-beta.</p>
Journal
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- Biomedical Research
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Biomedical Research 44 (1), 17-29, 2023-01-25
Biomedical Research Press