Eczema phenotypes and IgE component sensitization in adolescents: A population-based birth cohort
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- Kiguchi Tomoyuki
- Allergy Center, National Center for Child Health and Development
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- Yamamoto-Hanada Kiwako
- Allergy Center, National Center for Child Health and Development
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- Saito-Abe Mayako
- Allergy Center, National Center for Child Health and Development
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- Fukuie Tatsuki
- Allergy Center, National Center for Child Health and Development
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- Ohya Yukihiro
- Allergy Center, National Center for Child Health and Development
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<p>Background: Eczema patients are commonly immunoglobulin (Ig)E polysensitized. Although atopic dermatitis (AD) phenotypes have been recognized, IgE sensitization patterns based on AD phenotypes have not been well illustrated. We aimed to investigate how eczema phenotypes impact IgE component sensitization patterns.</p><p>Methods: This birth cohort study investigated a general population in the Tokyo Children's Health, Illness, and Development Study (T-Child Study) until children reached the age of 13 years. Eczema was assessed using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Allergen component specific IgE antibody titers were measured using a multiplex array ImmunoCAP ISAC.</p><p>Results: Persistent eczema phenotype until adolescence was strongly associated with allergic march symptoms, such as wheezing and hay fever, and oral allergy symptoms, and IgE component sensitizations of airborne (Japanese cedar, house dust mite, Timothy, cat, and dog) and cross-reactive allergens (Bet v 1 family) compared to early-remission and late-onset eczema. On the other hand, late-onset eczema did not show any strong associations with allergic symptoms and IgE sensitization. Adolescents with persistent eczema have high comorbidity of symptoms of pollen-food allergy syndrome.</p><p>Conclusions: Early-onset eczema is deeply connected with the later allergic march, and late-onset eczema differs from the phenotype of allergic march. Early-onset eczema characterizing IgE sensitization was likely to be an extrinsic type, and late-onset eczema, which was not related to IgE sensitization, was likely an intrinsic type. Pollen-Food Allergy Syndrome is one of the allergic features in allergic march.</p>
収録刊行物
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- Allergology International
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Allergology International 72 (1), 107-115, 2023
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390576502651825152
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可