A multicenter investigation of risk factors for recurrence in elderly patients with stage II colorectal cancer

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<p>Purpose: To clarify whether the risk factors for high-risk stage II colorectal cancer (CRC) indicated in the treatment guidelines can be applied to elderly CRC patients.</p><p>Methods: We analyzed 228 stage II CRC patients aged 75 years or older from a prospectively collected database from January 2001 to December 2015 to identify risk factors for recurrences.</p><p>Results: The recurrence-free survival rates at 1-, 3-, and 5 years after surgery were 94.0%, 84.6%, and 81.5%, respectively. A univariate analysis revealed that the gender, tumor location, and T status were related to outcomes. In a multivariate Cox proportional-hazards regression analysis, the T status was a significant risk factor for recurrence. Risk factors for the T3 group were examined in a sub-group analysis. A univariate analysis revealed that the gender was related to outcomes. In a multivariate Cox proportional-hazards regression analysis, the gender was a significant risk factor for recurrence. Risk factors for the T4 group were examined in a sub-group analysis. A univariate analysis revealed that the tumor location was related to outcomes. In a multivariate Cox proportional-hazards regression analysis, the tumor location was a significant risk factor for recurrence.</p><p>Conclusion: This study revealed that only T4 lesion was a risk factor for recurrence of stage II CRC in elderly patients. It is possible that not all risk factors listed in the guidelines apply to elderly patients. Adjuvant chemotherapy should be considered for elderly stage II CRC patients with T4 factor.</p>

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