Hypothyroid myopathy in a patient with MCTD with Hashimoto’s disease.

DOI
  • Tanaka Satona
    Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University
  • Shimizu Masaki
    Department of Child Health and Development, Tokyo Medical and Dental University
  • Shimbo Asami
    Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University
  • Yamazaki Susumu
    Department of Lifetime Clinical Immunology, Tokyo Medical and Dental University
  • Takasawa Kei
    Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University
  • Kashimada Kenichi
    Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University
  • Morio Tomohiro
    Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University
  • Mori Masaaki
    Department of Lifetime Clinical Immunology, Tokyo Medical and Dental University

Bibliographic Information

Other Title
  • 橋本病を合併した混合性結合組織病の1例：hypothyroid myopathyの鑑別の重要性

Search this article

Abstract

<p>There are various causes of hypercreatine kinasemia (hyperCKemia) including rheumatic diseases and hypothyroidism. Here, we reported the case of mixed connective tissue disease (MCTD) complicated with Hashimoto’s disease (HD), who developed hyperCKemia with each exacerbations of MCTD and HD. A 9-year-old girl with recurrent Raynaud’s phenomenon since the age of 7 years, developed fever, abdominal pain, neck pain, torticollis with cervical lymphadenopathy, hyperCKemia, and hypothyroidism. She was diagnosed with MCTD complicated with HD, and achieved remission with methylprednisolone pulse therapy. Thereafter, mycophenolate mofetil (MMF) was added, and remission was maintained. Levothyroxine (LT) was also started and was stopped after 4 months as thyroid function normalized. At the age of 10 years, the patient presented with abdominal pain, vomiting, and hyperCKemia, which was suspected to be an exacerbation of MCTD. However, at the same time, the exacerbation of hypothyroidism was also seen. LT was restarted and her symptoms were improved soon. At the age of 12, she developed neck pain, torticollis, and hyperCKemia again. Thyroid function was preserved with LT. The exacerbation of MCTD was suspected, and her symptoms and hyperCKemia improved after the doses of PSL increased. MCTD is frequently complicated with HD. Hypothyroid myopathy should be considered as a cause of hyperCKemia in patients with MCTD.</p>

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top