Epstein–Barr virus encephalitis following unrelated peripheral blood stem cell transplantation in a child with AML

DOI
  • Tamura Yumi
    Department of Pediatrics, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital Department of Pediatrics, Hiroshima University Hospital
  • Shiraishi Yasutaka
    Department of Pediatrics, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital Department of Pediatrics, Hiroshima City Funairi Citizens Hospital
  • Chizimatsu Ikue
    Department of Pediatrics, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital Matsuo Hospital
  • Tsuboi Ayana
    Department of Pediatrics, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital Department of Pediatrics, Hiroshima Prefectural Hospital
  • Ohno Norioki
    Department of Pediatrics, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
  • Miki Mizuka
    Department of Pediatrics, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
  • Fujita Naoto
    Department of Pediatrics, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital

Bibliographic Information

Other Title
  • 非血縁者間末梢血幹細胞移植後にEBウイルス脳幹脳炎を発症した小児難治性急性骨髄性白血病の1例

Description

<p>Herein, we report a case of Epstein–Barr virus (EBV) brainstem encephalitis after unrelated peripheral blood stem cell transplantation (uPBSCT), the distinctive radiological features of which enabled early diagnosis and intervention. A 13-year-old boy with FLT3-ITD-positive acute myeloid leukemia underwent HLA-DR1 antigen one locus mismatched uPBSCT with pretreatment including anti-thymocyte globulin (ATG). On post-transplant day 104, the patient had an altered consciousness. Cranial magnetic resonance imaging revealed bilateral hyperintensities in the thalamus, hypothalamus, internal capsule, parahippocampal gyrus, and midbrain to medulla oblongata, whereas peripheral blood examination revealed a high percentage of CD20-positive lymphocytes, suggesting EBV encephalitis. Accordingly, rituximab was initiated, which was effective. The patient was later found to be positive for EBV-DNA in blood and cerebrospinal fluid samples. The patient recovered without any neurological sequelae. Caution should be exercised in similar cases with an increase in ATG conditioning due to the diversification of donor sources.</p>

Journal

Keywords

Details 詳細情報について

  • CRID
    1390576668413008640
  • DOI
    10.11412/jspho.59.435
  • ISSN
    21895384
    2187011X
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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