Emergence of extended-spectrum β-lactamases in clinical isolates of Salmonella enterica in Tehran, Iran

DOI Web Site Web Site 被引用文献1件
  • Hamidian Mohammad
    The Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Iran
  • Tajbakhsh Mercedeh
    The Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Iran
  • Walther-Rasmussen Jan
    Department of Clinical Microbiology, 9301, The National University Hospital, Denmark
  • Zali Mohammad-Reza
    The Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Iran

書誌事項

タイトル別名
  • Emergence of Extended-Spectrum β-Lactamases in Clinical Isolates of <i>Salmonella enterica</i> in Tehran, Iran
  • Emergence of extended spectrum b lactamases in clinical isolates of Salmonella enterica in Tehran Iran
  • Emergence of extended-spectrum β-lactamases in clinical isolates of <italic>Salmonella enterica</italic> in Tehran, Iran

この論文をさがす

説明

<p>The purpose of the current study was to investigate the presence and molecular type(s) of extended-spectrum β-lactamases (ESBLs) in Salmonella spp. isolates obtained from patients with diarrhea in hospitals of Tehran, Iran. Over a period of 17 months, 129 Salmonella spp. were isolated from fecal samples and tested for susceptibility using the Kirby-Bauer disk diffusion method; then, screening for ESBL-producing isolates and determination of their minimum inhibitory concentrations were carried out using the combined disk method and standard agar dilution method, respectively. The presence and type of ESBL-encoding genes were determined by PCR and sequence analysis. The isolates were all identified as Salmonella enterica of different serovars. The highest resistance in the collected Salmonella isolates was to nalidixic acid (45.7%), followed by tetracycline (43.4%), trimethoprim-sulfamethoxazole (36.4%), ampicillin (15.5%), and chloramphenicol (14.7%). All the isolates were susceptible to ciprofloxacin, gentamicin, and cefoxitin. Three S. enterica isolates were resistant to ampicillin, piperacillin, ceftazidime, cefotaxime, ceftriaxone, cefpodoxime, cephalothin, and aztreonam. PCR and DNA sequencing revealed that two of the three isolates harbored both a blaCTX-M-15 and a blaTEM gene while the third one carried only a blaCTX-M-15 gene. This is the first study providing structural data for a CTX-M-type β-lactamase produced by Salmonella isolates recovered in Iran.<tt> </tt></p>

収録刊行物

被引用文献 (1)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ