A case of undiagnosed Graves’ disease who developed thyroid storm and acute heart failure after COVID-19 vaccination

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  • Yajima Hisao
    Department of Emergency and Critical Care Medicine, Subaru Health Insurance Ota Memorial Hospital
  • Samejima Yusuke
    Department of Cardiology, Subaru Health Insurance Ota Memorial Hospital
  • Matsushima Junya
    Department of Emergency and Critical Care Medicine, Subaru Health Insurance Ota Memorial Hospital
  • Tsubouchi Yohei
    Department of Emergency and Critical Care Medicine, Subaru Health Insurance Ota Memorial Hospital
  • Kanazashi Hideaki
    Department of Emergency and Critical Care Medicine, Subaru Health Insurance Ota Memorial Hospital
  • Sakurai Keiji
    Department of Emergency and Critical Care Medicine, Subaru Health Insurance Ota Memorial Hospital
  • Nagashima Yoshinori
    Department of Cardiology, Subaru Health Insurance Ota Memorial Hospital
  • Akieda Kazuki
    Department of Emergency and Critical Care Medicine, Subaru Health Insurance Ota Memorial Hospital

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Other Title
  • 新型コロナワクチン初回接種後に甲状腺クリーゼを発症し急性心不全に陥った未診断バセドウ病の1例

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Stress, such as infection and ischemic heart disease, can cause thyroid storm. Thyroid storm occurs mostly from Graves’ disease, which may be unnoticed and undiagnosed. In recent years, there have been increasing reports of Graves’ disease developing after COVID-19 vaccination. Here, we report a case in which a patient developed thyroid storm after the first COVID-19 vaccination, and was subsequently diagnosed with Graves’ disease. The patient was a 67-year-old man with no medical history. He was admitted for emergency treatment due to fatigue and dyspnea that began the morningafter receiving a COVID-19 vaccination. Acute ischemic heart failure was diagnosed by electrocardiography and cardiac catheterization, and he was admitted to the ICU after treatment. Tachycardia continued from the time of admission, and he subsequently developed high fever. Thyroid function tests revealed thyroid storm and Graves’ disease. The development of thyroid storm after vaccination should be kept in mind as well as sudden illness and trauma.

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