Cerium (IV) Oxide Nanoparticles Enhance Hepatotoxic and Nephrotoxic Effects of Paraquat, Cisplatin, or Acetaminophen in Mice

DOI Web Site 参考文献24件 オープンアクセス
  • Takahashi Yoshihiro
    Graduate School of Pharmaceutical Sciences, Teikyo Heisei University
  • Ishida Isao
    Graduate School of Pharmaceutical Sciences, Teikyo Heisei University
  • Isoda Katsuhiro
    Graduate School of Pharmaceutical Sciences, Teikyo Heisei University

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説明

<p>Nanomaterials are central to nanotechnology and have many useful properties. Cerium(IV) oxide nanoparticles (nCeO) have catalytic and antioxidant activity, and hold promise in industrial and medical products. However, the potential biological hazards of nCeO have not been addressed. We therefore investigated the in vivo effects and drug interactions of nCeO. Tail vein administration of nCeO did not induce liver and kidney injury in mice but induced liver or kidney damage when co-administered with paraquat, cisplatin or acetaminophen. Therefore, our findings indicate that nCeO are potentially hepatotoxic and nephrotoxic due to drug interactions.</p>

収録刊行物

  • BPB Reports

    BPB Reports 6 (2), 33-36, 2023

    公益社団法人 日本薬学会

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