骨分化誘導剤に応じたアクチンフィラメントが骨細胞スフェロイドの機械的挙動を変化させる

DOI Web Site

書誌事項

タイトル別名
  • Generation of tight actin filaments in response to osteogenesis supplements modulated the mechanical behaviors of osteocyte spheroids

抄録

<p>Previously, we have developed scaffold-free osteocytic spheroids using osteoblast precursor cells and mesenchymal stem cells. In this study, using spheroids reconstructed by human mesenchymal stem cells, we aimed to elucidate the cellular behaviors of the osteocytic spheroids in response to chemically induced osteogenesis supplements. In the presence of the osteogenesis supplements, the spheroids exhibited a greater size reduction after 7 days. We also found out the osteogenesis supplements generated tight actin filaments on the surface of the spheroids, which results in the further size reduction of the spheroids compared to the non-treated one. From these results, we represented that the cellular behaviors of the osteocytic spheroids are altered by the chemical induction.</p>

収録刊行物

  • 年次大会

    年次大会 2022 (0), S021-08-, 2022

    一般社団法人 日本機械学会

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ