Steroid therapy and rehabilitation in the treatment in a patient with delayed neurological sequelae due to carbon monoxide poisoning : A case report.

Mimura Yu, Oi Hiroki, Takata Taketo, Mimura Masaru, Funayama Michitaka

doi:10.57388/jjct.36.1_32

Bibliographic Information

Other Title

一酸化炭素中毒による遅発性脳症に対してステロイドパルスおよび後療法とリハビリテーションを行った1例
イッサンカタンソチュウドクニヨルチハツセイノウショウニタイシテステロイドパルスオヨビアトリョウホウトリハビリテーションオオコナッタ 1レイ

Search this article

Abstract

<p>We herein report on a man in his thirties with delayed neurological sequelae (DNS) associated with carbon monoxide (CO) intoxication. He was found to be in a deep coma state in his room and subsequently transferred to our emergency department. His mental status gradually improved over the next 29 days, however, neuropsychological examinations revealed he had neurocognitive impairments. On day 29, he was found to be in disturbance of consciousness again, and at that time, we diagnosed he had DNS due to CO poisoning. He had been in a deep coma state for 12 weeks, but his symptoms remarkably improved after the sustained immunosuppressive therapy, mainly methylprednisolone and rehabilitation. We had routinely checked up on myelin basic protein (MBP) levels in his cerebrospinal fluid, which showed monotonical improvements. Our presented case suggested that impaired consciousness levels would recover with persistent corticosteroid therapy in a patient with DNS associated with CO poisoning, and MBP would be a useful biomarker, which reflects the severity of demyelination in central nervous systems.</p>

Journal

Japanese Journal of Clinical Toxicology

Japanese Journal of Clinical Toxicology 36 (1), 32-37, 2023-03-10

Japanese Society for Clinical Toxicology

Keywords

Details 詳細情報について

Export