Safe administration of sotrovimab to a COVID-19 patient with acute phase type 1 diabetes mellitus
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- Tanaka Haruna
- Department of Endocrinology and Metabolism, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan
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- Matsumoto Masaaki
- Department of Endocrinology and Metabolism, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan
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- Hong Sung Won
- Department of Endocrinology and Metabolism, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan
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- Mitsuboshi Akari
- Department of Endocrinology and Metabolism, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan
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- Nagai Masashi
- Department of Endocrinology and Metabolism, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan
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- Yoshino Go
- Division of Infectious Disease, Department of Pediatrics, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan
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- Otake Shogo
- Division of Infectious Disease, Department of Pediatrics, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan
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- Matsuo Susumu
- Department of Pediatrics, Toyooka Hospital, Hyogo, Japan
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- Yamada Hiroyuki
- Department of Pediatrics, Toyooka Hospital, Hyogo, Japan
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- Kurosawa Hiroshi
- Division of Pediatric Critical Care Medicine, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan
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- Kasai Masashi
- Division of Infectious Disease, Department of Pediatrics, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan
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- Ozaki Kayo
- Department of Endocrinology and Metabolism, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan
抄録
<p>Type 1 diabetes mellitus (T1DM) and poor glycemic control are risk factors for severe coronavirus disease 2019 (COVID-19). Sotrovimab can treat mild-to-moderate COVID-19 in patients at a high risk of progression to severe COVID-19. However, its safety and efficacy in T1DM patients remain to be elucidated. We report the case of a 12-yr-old patient who was treated with sotrovimab for COVID-19 immediately after treatment for diabetic ketoacidosis (DKA) due to new-onset T1DM. He presented with nausea and sore throat and was diagnosed with severe DKA and COVID-19. A productive cough and sputum developed after admission. On the 3rd day of admission, the DKA resolved, and sotrovimab was administered to prevent exacerbation of COVID-19. Although the blood glucose levels increased after the administration of sotrobimab, there was no recurrence of DKA. Hyperglycemia may be a sotrovimab-related adverse event in T1DM patients. Nevertheless, the benefits of sotrovimab treatment may far outweigh the potential risks. Thus, sotrovimab was considered safe for patients with T1DM immediately after treatment of severe DKA.</p>
収録刊行物
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- Clinical Pediatric Endocrinology
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Clinical Pediatric Endocrinology 32 (2), 110-113, 2023
日本小児内分泌学会
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詳細情報 詳細情報について
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- CRID
- 1390577133276071808
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- ISSN
- 13477358
- 09185739
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可