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- 小島 徹
- 埼玉県立がんセンター 放射線治療科
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- 川村 愼二
- 帝京大学 大学院保健学研究科
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- 大谷 侑輝
- 市立貝塚病院 放射線科
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- 山田 崇裕
- 近畿大学 原子力研究所
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- 岡本 裕之
- 国立がん研究センター中央病院 放射線品質管理室
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- 加茂前 健
- 名古屋大学医学部附属病院 放射線科
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- 山下 修
- 金沢医科大学病院 医療技術部 診療放射線技術部門
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- 大下 崇
- 東京慈恵会医科大学附属病院 放射線部
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- 黒澤 忠弘
- 産業技術総合研究所計量標準総合センター
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- 脇谷 雄一郎
- 公益社団法人日本アイソトープ協会
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- 花田 剛士
- 慶應義塾大学医学部 放射線科学教室(治療)
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- 萬 篤憲
- 国立病院機構東京医療センター 放射線治療科
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- 浪花 健太
- 株式会社千代田テクノル
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- 茂藤 隆広
- 株式会社メディコン
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- 長谷川 軍司
- 日本メジフィジックス株式会社
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- 古畑 優
- アクロバイオ株式会社
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- 藤井 克尚
- ユーロメディテック株式会社
書誌事項
- タイトル別名
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- Technical Report: Quality Assurance for <sup>125</sup>I Seed Sources in Permanent Prostate Brachytherapy
この論文をさがす
抄録
<p>This technical report provides useful information on the current status and issues of quality control in 125I seed source strength measurement for Permanent Prostate Brachytherapy in Japan.</p><p>With the spread of 125I seed brachytherapy, the traceability of source strength measurements with the single-seed assay was established in Japan. This allows medical facilities to measure reference air kerma rate of 125I seeds with their own well-type of ionization chamber. However, it is difficult to maintain the traceability chain because the 125I reference air kerma rate standards have been hardly utilized by medical facilities so far. Meanwhile, some serious incidents of contamination of the different source strengths and dead seeds were reported in Japan.</p><p>To address the specific issues in Japan, JASTRO Brachytherapy Subcommittee established a working group (WG) in 2021. The goal of this WG is to investigate the management methods of source strength measurement used in medical facilities, and to discuss the ideal and practicable methods of source management such as verifying the number of seeds and source strength. Initially, a questionnaire survey was conducted to facilities offering 125I seed brachytherapy in Japan. Sixty-seven out of 95 facilities responded (response rate 70.5%). This survey revealed that 41% of facilities did not perform either confirmation of the number of seeds or measurement of source strength. There are several reasons why the source strength was not measured in those facilities. For example, 125I seeds are provided under the sterilized conditions; quality assurance by source suppliers is reliable; and there is not sufficient staff.</p><p>The single-seed assay is regarded as an internationally standardized and the most reliable measurement method. Therefore, it is an essential measurement technique to ensure traceability of source strength measurements. However, our survey found that most Japanese facilities do not perform single-seed assays. Meanwhile, some facilities have performed batch assay as an alternative method, in which all of the multiple sources in a batch are measured while loaded into sterilized cartridges. Although the measurement by the batch assay is less accurate than the one by the single-seeded assay, the batch assay does not require re-sterilization of the source and can be performed quickly. It might be useful to detect unexpected errors such as differences in the number of sources and abnormalities in source strength.</p><p>In this report, we will introduce several methods of source strength measurement that have been implemented in medical facilities. The quality assurance of 125I seed sources in prostate interstitial brachytherapy should be provided not only by the source suppliers but also by the medical facilities that use sources to treat patients. We hope that medical facilities will refer to this technical report and use it as an aid to quality assurance in their own facilities.</p>
収録刊行物
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- 医学物理
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医学物理 43 (1), 1-16, 2023-04-12
公益社団法人 日本医学物理学会