In vitro Distribution of Added 32P-labeled Lecithin, Sphingomyelin and Lysolecithin in Plasma Lipoproteins and their Exchange with Erythrocyte Phospholipids.

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When phospholipids, such as lecithin, lysolecithin and sphingomyelin separated from rat plasma, were added into rat plasma in vitro respectively, their distribution patterns into plasma lipoproteins were ultracentriufgally same with those obtained in vivo. That is, lecithin and sphingomyelin were mainly distributed in HDL and LDL fractions, while lysolecithin was concentrated in the fraction of density greater than 1.21.Individual phospholipids added into plasma in vitro could be exchanged with erythrocyte phospholipids and the extent of exchange was greatest in lysolecithin. The exchanges of lecithin and sphingomyelin were less active, although the former was more active than the latter.Investigation on participation of plasma lipoprotein in the exchange of phospholipids between plasma and erythrocytes during incubation showed that two major lipoproteins, HDL and LDL, partook principally in the exchange of lecithin and sphingomyelin. On the other hand, the lipoprotein fraction of a density greater than 1.21 participated mainly in the exchange of lysolecithin. These results were in good agreement with those obtained from the studies with native plasma, in which these phospholipids were already present as components of plasma lipoprotein, and it was found, therefore, that the phospholipids added in plasma in vitro behaved same as native phospholipids in plasma.It was clearly noticed that in plasma the conversion of lecithin into lysolecithin could occur during the incubation.

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